The Barnes family of doctors inhabits the sitcom world of "Out of Practice." Parents Stewart (Henry Winkler), a gastroenterologist, and Lydia (Stockard Channing, Bright Young Things, A Girl Thing, The Business of Strangers, The Truth About Jane, The First Wives Club, Bitter Moon), a hotshot cardiologist, are divorced. Brother Ben (Christopher Gorham) is a mild mannered marriage counselor; brother Oliver (Ty Burrell) a self-centered plastic surgeon; and sister Regina (Paula Marshall) an emergency room doctor. Stewart is also dating the much younger Crystal (Jennifer Tilly, Relax... It's Just Sex, Bound, Embrace of the Vampire), his secretary.

Within the first ten minutes of the pilot, the siblings are discussing dating and significant others, and Regina's status as a lesbian is bantered about. She and her brother Oliver both have an eye for beautiful women.

In episode seven, Regina and her mother have a nice discussion about Lydia's support for her daughter, this following Lydia being mistaken for a lesbian herself. Episode nine sees a flashback of Regina coming out to her family seven years earlier when she steals Oliver's date, and two of her ex-girlfriends actually kiss in episode twelve.

It's an adult comedy with a great cast and a lesbian character who is acknowledged as such by her family. Regina's sexual orientation is referenced in every episode, perhaps a good example of the rare mainstreaming of lgbt characters on television.